Roundtable Discussion: Innovations in Addressing Purification Challenges to Produce High Quality mRNA Therapeutics & Vaccines
Time: 11:00 am
day: Conference Day One
Details:
- What the best methods for mRNA purification?
- Do they change with scale?
- Does a two-step purification significantly improve purity?
- Under what circumstances (volume, throughput) do the continuous purification methods offer significant advantage?
- For dsRNA:
- What are the best approaches to reduce dsRNA during IVT
- Which forms are dominant and which forms are immunogenic
- What are the best analytical methods for dsRNA quantitation?
- What is the current regulatory guidance regarding dsRNA?
