Posts by cayleedonaldson
Advancing CAR-T Cell Therapies: A Novel High-Throughput Image Cytometry Method for Assessing Cytotoxicity in 3D Tumor Spheroids
Introduction: Cancer, particularly solid tumors, continues to claim lives, demanding the urgent need for innovative cellular therapies. Chimeric antigen receptor T cells (CAR-T cells) have emerged as a potential solution, with six CAR-T cell therapies already FDA-approved for hematologic B cell malignancies. However, solid tumors present unique challenges, warranting novel, high-throughput testing methodologies to assess…Read more
Read MoreNovel In Vitro Assays Pave Way for More Potent Anti-Cancer CAR T-Cell Therapies
Research paper overview and breakthrough in CAR T-cell potency assessment against GBM The research paper ‘Label-free in vitro assays predict the potency of anti-disialoganglioside chimeric antigen receptor T-cell products’ authored by Meghan Logun and a team of researchers demonstrates a breakthrough in assessing the potency of CAR T-cell therapies against glioblastoma (GBM), a type of…Read more
Read MoreThe Cellular Revolution: Exploring the Latest Advancements in Cell Therapies
Cell therapies, a cutting-edge approach in modern medicine involving the transfer of cells from a donor or the patient themselves for therapeutic use, have begun to revolutionize medical treatment as we know it. Initially confined to bone marrow transplantation for leukemia, the sphere of cell therapies has grown exponentially, largely due to breakthroughs in stem…Read more
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