CellXpose
Illuminating the Frontier of Cell Therapies through the Latest Research, News and Literature
MSC Therapies: The Promise and the Hurdles
Research Paper Overview: Therapeutic Use of Mesenchymal Stromal Cells The research paper ‘Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species’ by Adrienne Wright, Marne L. Arthaud-Day, and Mark L. Weiss explores the therapeutic potential of multipotent mesenchymal stromal cells (MSCs) and their wide applicability…Read more
Potency Testing in Cell and Gene Therapy: A Deep Dive
Research Paper Overview: Navigating the Complexities of Potency Testing in Cell and Gene Therapy Products The research paper ‘Potency testing of cell and gene therapy products’ by Paula Salmikangas, Björn Carlsson, Christophe Klumb, Tatiana Reimer, and Steffen Thirstrup, delves into the complexities and significance of potency assessment in biological medicinal products, particularly in Cell and…Read more
Workshop Summary: Integrating Functional Assay Readouts for In Vivo Insights
Integrating Functional Assay Readouts for In Vivo Insights Cell therapies are revolutionizing medicine’s horizon and precise analytical development is the secret weapon. The recent Cell Therapy Analytical Development Searchlight workshop dove into this exhilarating space, spotlighting the dance between potency assays and efficacy. Led by Cheryl Cox and Nathan Majewski, this workshop highlighted the intertwining…Read more
Advancing CAR-T Cell Therapies: A Novel High-Throughput Image Cytometry Method for Assessing Cytotoxicity in 3D Tumor Spheroids
Introduction: Cancer, particularly solid tumors, continues to claim lives, demanding the urgent need for innovative cellular therapies. Chimeric antigen receptor T cells (CAR-T cells) have emerged as a potential solution, with six CAR-T cell therapies already FDA-approved for hematologic B cell malignancies. However, solid tumors present unique challenges, warranting novel, high-throughput testing methodologies to assess…Read more
Novel In Vitro Assays Pave Way for More Potent Anti-Cancer CAR T-Cell Therapies
Research paper overview and breakthrough in CAR T-cell potency assessment against GBM The research paper ‘Label-free in vitro assays predict the potency of anti-disialoganglioside chimeric antigen receptor T-cell products’ authored by Meghan Logun and a team of researchers demonstrates a breakthrough in assessing the potency of CAR T-cell therapies against glioblastoma (GBM), a type of…Read more
The Cellular Revolution: Exploring the Latest Advancements in Cell Therapies
Cell therapies, a cutting-edge approach in modern medicine involving the transfer of cells from a donor or the patient themselves for therapeutic use, have begun to revolutionize medical treatment as we know it. Initially confined to bone marrow transplantation for leukemia, the sphere of cell therapies has grown exponentially, largely due to breakthroughs in stem…Read more